fak inhibitor 14 Search Results


fak inhibitor fi 14  (Tocris)
94
Tocris fak inhibitor fi 14
Fak Inhibitor Fi 14, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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y15  (MedChemExpress)
94
MedChemExpress y15
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
Y15, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
y15 - by Bioz Stars, 2026-02
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1 2 4 5 benzenetetraamine tetrahydrochloride  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology 1 2 4 5 benzenetetraamine tetrahydrochloride
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
1 2 4 5 Benzenetetraamine Tetrahydrochloride, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fak inhibitor 14 f114  (Tocris)
93
Tocris fak inhibitor 14 f114
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
Fak Inhibitor 14 F114, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fak inhibitor 14  (Cayman Chemical)
90
Cayman Chemical fak inhibitor 14
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
Fak Inhibitor 14, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fak inhibitor i 324877  (Merck KGaA)
90
Merck KGaA fak inhibitor i 324877
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
Fak Inhibitor I 324877, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fak inhibitor 14  (Biomol GmbH)
90
Biomol GmbH fak inhibitor 14
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
Fak Inhibitor 14, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fak inhibitor 14/product/Biomol GmbH
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fak inhibitor 14 - by Bioz Stars, 2026-02
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fak inhibitor 14 sc-203950/y15  (CureFAKtor Pharmaceuticals LLC)
90
CureFAKtor Pharmaceuticals LLC fak inhibitor 14 sc-203950/y15
The FAK <t>inhibitor-Y15</t> repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.
Fak Inhibitor 14 Sc 203950/Y15, supplied by CureFAKtor Pharmaceuticals LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fak inhibitor 14 sc-203950/y15/product/CureFAKtor Pharmaceuticals LLC
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Image Search Results


The FAK inhibitor-Y15 repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.

Journal: American Journal of Cancer Research

Article Title: Linc00662 m 6 A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway

doi:

Figure Lengend Snippet: The FAK inhibitor-Y15 repressed the malignant progression of PC. A. Linc00662-overexpressing PC cells were treated with Y15 at different concentrations to identify the suitable concentrations. The results of western blotting showed that 2 µM and 5 µM of Y15 were the suitable concentrations in BxPC-3 cells and PANC-1 cells, respectively, which inhibited FAK autophosphorylation activity without effect on FAK expression. B. Western blotting showed that Y15 treatment dramatically repressed the levels of p-FAK, p-Paxillin, and p-Erk in PC cells. C. The CCK8 assay showed that Y15 treatment significantly reversed the increased proliferative capacity of Linc00662-overexpressing PC cells. D. The wound healing assay indicated that Y15 treatment significantly reversed the increased migratory capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. E. The transwell assay indicated that Y15 treatment significantly reversed the increased invasive capacity of Linc00662-overexpressing PC cells, magnification: 100 ×. F. A mouse xenograft model was used to evaluate the effect of Y15 on cell growth in vivo. Images of transplanted subcutaneous tumors were displayed. G. Y15 treatment dramatically repressed tumor volume in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. H. Y15 treatment dramatically repressed subcutaneous tumor weight in mice bearing Linc00662-overexpressed PC cells. *: P < 0.05. Abbreviations: PC: pancreatic cancer, CCK8: cell counting kit-8.

Article Snippet: After 1 week, pre-established tumor xenografts were treated with Y15 (0.5 mg/kg, 2 ×/week × 3) (MCE, New Jersey, China).

Techniques: Western Blot, Activity Assay, Expressing, CCK-8 Assay, Wound Healing Assay, Transwell Assay, In Vivo, Cell Counting

Schematic model on the role of Linc00662 in regulating PC malignant progression through the GTF2B-ITGA1-FAK pathway. This study proposes a novel regulatory mechanism of Linc00662 in oncogene activation in PC. Linc00662 activates the transcription of ITGA1 by recruiting GTF2B in a m6A-dependent manner and promotes PC cell proliferation, invasion, and migration, which partly relies on the activation of focal adhesions through the ITGA1-FAK-Erk pathway. And Y15 treatment inhibits autophosphorylation of FAK and obviously represses tumor progression of Linc00662-overexpressing PC cells. Abbreviations: PC: pancreatic cancer, GTF2B: general transcription factor II-B, ITGA1: integrin alpha-1, m6A: N6-methyladenosine.

Journal: American Journal of Cancer Research

Article Title: Linc00662 m 6 A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway

doi:

Figure Lengend Snippet: Schematic model on the role of Linc00662 in regulating PC malignant progression through the GTF2B-ITGA1-FAK pathway. This study proposes a novel regulatory mechanism of Linc00662 in oncogene activation in PC. Linc00662 activates the transcription of ITGA1 by recruiting GTF2B in a m6A-dependent manner and promotes PC cell proliferation, invasion, and migration, which partly relies on the activation of focal adhesions through the ITGA1-FAK-Erk pathway. And Y15 treatment inhibits autophosphorylation of FAK and obviously represses tumor progression of Linc00662-overexpressing PC cells. Abbreviations: PC: pancreatic cancer, GTF2B: general transcription factor II-B, ITGA1: integrin alpha-1, m6A: N6-methyladenosine.

Article Snippet: After 1 week, pre-established tumor xenografts were treated with Y15 (0.5 mg/kg, 2 ×/week × 3) (MCE, New Jersey, China).

Techniques: Activation Assay, Migration